No cytogenetic effects of quinolone treatment in humans
| Autor: | R Norrby, Felix Mitelman, Bodil Strömbeck, P Sommer, A.-M. Kolnig, J Wadstein, B Kromann-Andersen |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Ofloxacin medicine.drug_class Lymphocyte Biology Gastroenterology Anti-Infective Agents Ciprofloxacin Internal medicine Oxazines medicine Humans Pharmacology (medical) Antibacterial agent Aged Pharmacology Aged 80 and over Chromosome Aberrations Cytogenetics Middle Aged Quinolone Infectious Diseases medicine.anatomical_structure Toxicity Immunology Quinolines Female medicine.drug Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 32(6) |
| ISSN: | 0066-4804 |
| Popis: | Cytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in any treatment group. The mean aberration yields for each cytogenetic parameter studied and the total number of aberrations were all normal at each sampling occasion. |
| Databáze: | OpenAIRE |
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