Adjuvant hypofractionated radiation therapy for breast cancer after conserving surgery
| Autor: | Marco Stefanacci, Giampaolo Biti, Silvia Scoccianti, D Dicosmo, Fabiano Nosi, Simona Borghesi, Fabiola Paiar, Lorenzo Livi, Monica Mangoni, A Chiavacci, P. Ponticelli, Gabriele Simontacchi, Jacopo Nori |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Hypofractionated Radiation Therapy
Segmental Mastectomy Segmental Ductal 80 and over Breast Dose Fractionation Adjuvant Mastectomy Aged 80 and over Carcinoma Ductal Breast Late effect Radiotherapy Dosage Middle Aged Combined Modality Therapy Survival Rate medicine.anatomical_structure Oncology Local Chemotherapy Adjuvant Female medicine.symptom Menopause Adult Aged Axilla Breast Neoplasms Carcinoma Lobular Follow-Up Studies Humans Lymph Node Excision Neoplasm Recurrence Local Neoplasm Staging Radiotherapy Adjuvant medicine.medical_specialty Lobular Breast cancer medicine Chemotherapy Radiology Nuclear Medicine and imaging Survival rate Radiotherapy business.industry Carcinoma Dose fractionation Cosmesis medicine.disease Surgery Neoplasm Recurrence Dose Fractionation Radiation business |
| Popis: | Aims To evaluate the incidence of locoregional recurrence (LRR) and the cosmetic results in a group of patients with breast cancer treated with a hypofractionated schedule of adjuvant radiotherapy after conservative surgery. Materials and methods In total, 539 patients with pTis–pT1–pT2 breast cancer underwent radiotherapy treatment after conservative surgery at the University of Florence and at the Pistoia Hospital. The dose delivered was 44Gy (2.75Gy daily fraction). The tumour bed boost (10Gy) was given by electrons. Results At the time of the analysis, 1.8% of patients (10/539) had breast relapse. No patients developed nodal recurrence (supraclavicular, axillary and internal mammary nodes). The 3- and 5-year actuarial rates for LRR were 1.2% (±0.5% standard error) and 2.1% (±0.6% standard error), respectively. Considering the late toxicity, we found that 412 (76.4%) patients had grade 0 or grade 1 late toxicity, 113 patients (20.9%) had grade 2 late toxicity and 14 patients (2.5%) had grade 3 late toxicity. No patients developed grade 4 toxicity. Conclusion This type of approach resulted in an effective treatment in terms of local control in patients with negative or one to three positive axillary nodes and negative surgical margins. Patients treated with a hypofractionated schedule showed very good cosmesis. |
| Databáze: | OpenAIRE |
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