Bilateral multiple serous retinal detachments after treatment with nivolumab: a case report

Autor: Akiyuki Kawamura, Koji Tanaka, Hajime Onoe, Yu Wakatsuki, Ryusaburo Mori, Reina Miyamoto, Hiroyuki Nakashizuka
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Indocyanine Green
Male
medicine.medical_specialty
genetic structures
Posterior pole
Nose Neoplasms
Visual Acuity
Case Report
Fundus (eye)
Serous Retinal Detachment
Fundus autofluorescence
03 medical and health sciences
chemistry.chemical_compound
Immune checkpoint inhibitors
0302 clinical medicine
Antineoplastic Agents
Immunological
lcsh:Ophthalmology
Ophthalmology
medicine
Humans
Fluorescein Angiography
Coloring Agents
Melanoma
Aged
medicine.diagnostic_test
business.industry
Choroid
Retinal Detachment
Retinal
General Medicine
Serous retinal detachment
Fluorescein angiography
Photoreceptor outer segment
eye diseases
Serous fluid
medicine.anatomical_structure
Nivolumab
chemistry
lcsh:RE1-994
030221 ophthalmology & optometry
sense organs
Nasal Cavity
business
030217 neurology & neurosurgery
Tomography
Optical Coherence
Photoreceptor Cells
Vertebrate
Zdroj: BMC Ophthalmology, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Ophthalmology
ISSN: 1471-2415
DOI: 10.1186/s12886-020-01495-w
Popis: Background Immune checkpoint inhibitors have recently been widely used for advanced cancers and are known to cause ocular complications. We herein report a case developing bilateral serous retinal detachments, without ocular inflammation, after starting nivolumab treatment. Case presentation A 73-year-old man was referred to our hospital, having become aware of metamorphopsia 2 months after starting nivolumab (anti-programmed cell death protein 1 monoclonal antibody) for malignant melanoma of the nasal cavity. The initial corrected visual acuity of the right eye was 20/20, and that of the left eye was 20/16. There were no inflammatory findings in the anterior segment or the vitreous. Vitelliform lesions were found in the macular area of both ocular fundi, consistent with serous retinal detachment and subretinal deposits. Swept source optical coherence tomography showed diffuse thickening of the outer photoreceptor segment and thickening of the choroid. Two months after the initial diagnosis, multiple vitelliform lesions were noted, and the fundus findings had worsened. Indocyanine green fluorescein angiography showed delayed inflow in the peripapillary and posterior pole regions in the early phase of imaging. Fundus autofluorescence showed hyperautofluorescence consistent with most of the vitelliform lesions on color fundus photography. Conclusions Nivolumab may have impaired the pumping and phagocytosis functions of retinal pigment epithelial cells, resulting in bilateral serous retinal detachments and thickening of the photoreceptor outer segment. This is the first case report, to our knowledge, describing multiple bilateral serous retinal detachments and outer segment thickening without inflammation in a patient treated with nivolumab.
Databáze: OpenAIRE
Externí odkaz: