The Complex Management of the Breast Angiosarcoma: A Retrospective Study
| Autor: | Lucia Cannella, Francesco Perri, Ottavia Clemente, Claudia von Arx, Antonio Pizzolorusso, Maurizio Di Bonito, Alessandra Bracigliano, Massimiliano Di Marzo, Giuseppina Della Vittoria Scarpati, Annarosaria De Chiara, Salvatore Tafuto |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Oncology. 101:234-239 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000525146 |
| Popis: | Background/Aim: Breast angiosarcoma is a rare and aggressive disease with a poor prognosis. Two subtypes have been identified: primary angiosarcoma (PBA) and secondary breast angiosarcoma (SBA). In this retrospective analysis, we describe and compare our institute experience with the data existing in the literature. Materials and Methods: We included in our analysis 29 patients who received a diagnosis of PBA or SBA between 2006 and 2019. Results: All patients received surgery as frontline treatment, but only 6 patients underwent to adjuvant treatment. Neoadjuvant chemotherapy was administered 2 patients. The preferred chemotherapeutic regimen was taxanes with or without gemcitabine and associated with anthracyclines. A lower median RFS and OS were reported in patients with PBA compared to those with SBA, but the difference observed was not statistically significant. Patients with PBA had a lower median age at the diagnosis (38 vs. 75). Conclusion: In our analysis, we have shown a lower median RFS and OS in patients with PBA compared with those with SBA, and a significantly younger age at diagnosis in patients affected by PBA. |
| Databáze: | OpenAIRE |
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