Cerebral toxoplasmosis in an allogeneic peripheral stem cell transplant recipient: case report and review of literature
| Autor: | L. Slovacek, P. Prasil, V. Hobza, V. Cerovsky, A. Kohout, L. Cibickova, Jiri Horacek |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pathology medicine.medical_specialty Stereotactic biopsy Biopsy Antiprotozoal Agents Disease Status epilepticus Polymerase Chain Reaction Stereotaxic Techniques Thalamus medicine Animals Humans Transplantation Homologous Peripheral Blood Stem Cell Transplantation Transplantation medicine.diagnostic_test business.industry Magnetic resonance imaging Histology Middle Aged Magnetic Resonance Imaging Peripheral stem cell transplantation Radiography Infectious Diseases Toxoplasmosis Cerebral Stereotaxic technique medicine.symptom business Toxoplasma |
| Zdroj: | Transplant Infectious Disease. 9:332-335 |
| ISSN: | 1399-3062 1398-2273 |
| DOI: | 10.1111/j.1399-3062.2007.00224.x |
| Popis: | We present a patient who underwent allogeneic peripheral stem cell transplantation (PSCT) for chronic myelocytic leukemia. Twenty months after the PSCT he experienced status epilepticus. Magnetic resonance imaging (MRI) revealed a focus in the ventral thalamus-hypothalamus region. Using stereotactic biopsy with histology and specific polymerase chain reaction investigation from brain tissue, cerebral toxoplasmosis was diagnosed and treated with antiparasitic therapy. Early recognition of such serious and potentially lethal disease enabled prompt specific treatment. This case report emphasizes the role of stereotactic biopsy in diagnosis of cerebral toxoplasmosis. Other methods such as MRI are non-invasive but not sufficiently specific and sensitive. |
| Databáze: | OpenAIRE |
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