Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms
| Autor: | Gabor Szalai, Omar Moussa, Amanda C. LaRue, Dennis K. Watson, John S. Yordy, Marey R. Shriver, David P. Turner, Brent D. McCarragher, Victoria J. Findlay, Patricia M. Watson |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty animal structures biology Slug Mechanism (biology) business.industry fungi Regulator Original Articles biology.organism_classification medicine.disease law.invention Metastasis Breast cancer law embryonic structures Genetics Cancer research Medicine Suppressor Epithelial–mesenchymal transition business Transcription factor |
| Zdroj: | Genes & Cancer. 2:120-129 |
| ISSN: | 1947-6027 1947-6019 |
| Popis: | The 5-year survival rate is very low when breast cancer becomes metastatic. The metastatic process is governed by a network of molecules of which SLUG is known to play a major role as a regulator of epithelial-to-mesenchymal transition (EMT). Prostate-derived ETS factor (PDEF) has been proposed as a tumor suppressor, possibly through inhibition of invasion and metastasis; therefore, understanding the mechanism of PDEF regulation may help to better understand its role in breast cancer progression. This study shows for the first time that the transcription factor SLUG is a direct target of PDEF in breast cancer. We show that the expression of PDEF is able to suppress/dampen EMT through the negative regulation of SLUG. In addition, we show that PDEF is also able to regulate downstream targets of SLUG, namely E-cadherin, in both SLUG-dependent and -independent manners, suggesting a critical role for PDEF in regulating EMT. |
| Databáze: | OpenAIRE |
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