Pre-treatment with simvastatin prevents LPS-induced hyporesponsiveness of porcine isolated coronary artery
| Autor: | S Chinniah, V. G. Wilson, Salmin Alshalmani, Ravi Mahajan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Statin Vascular smooth muscle biology business.industry medicine.drug_class Pharmacology Critical Care and Intensive Care Medicine medicine.disease Proinflammatory cytokine Sepsis Nitric oxide synthase medicine.anatomical_structure Simvastatin Poster Presentation medicine biology.protein lipids (amino acids peptides and proteins) Vasoconstrictor Agents business Artery medicine.drug |
| Zdroj: | Critical Care |
| ISSN: | 1466-609X 1364-8535 |
| Popis: | Several retrospective studies suggest that prior use of statins can reduce hospital mortality in patients diagnosed with either bacteraemia or sepsis. Simvastatin has been shown to modify the proinflammatory effect of lipopolysaccharide (LPS) on neutrophils and endothelial cells. However, it is not clear whether these effects are also manifest on vascular smooth muscle, which becomes hyporesponsive to vasoconstrictor agents due to the induction of nitric oxide synthase. We have investigated the effect of pre-treatment with simvastatin on LPS-induced changes in contractions of porcine isolated coronary artery (PCA). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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