Endogenous bile acid tolerance test for liver function
| Autor: | M. Van Blankenstein, F. J. W. Ten Kate, E. P. Bosman-Jacobs, J. W. O. Van Den Berg, M. Frenkel, A. C. Touw-Blommesteyn |
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| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Time Factors Physiology medicine.drug_class Radioimmunoassay Bile Acids and Salts Liver disease Liver Function Tests Internal medicine medicine Humans medicine.diagnostic_test Bile acid business.industry Liver cell Liver Diseases Gastroenterology Fasting Hepatology medicine.disease Endocrinology Postprandial Liver biopsy Liver function business |
| Zdroj: | Digestive diseases and sciences. 28(2) |
| ISSN: | 0163-2116 |
| Popis: | Fasting and postprandial (stimulated) serum conjugated bile acids (CBA) were measured by a solid-phase radioimmunoassay in 329 patients undergoing liver biopsy, and the results were analyzed for 231 who fitted into 10 diagnostic categories. In healthy volunteers the mean fasting CBA of 1.8 +/- 0.7 mumol/liter rose to 3.0 +/- 0.8 mumol/liter postprandially. In patients mean fasting and stimulated CBA were only significantly raised in moderate to severe chronic and acute liver disease. Diagnostic sensitivity was poor in mild liver disease. Individuals with normal results were found in 8 of 11 disease categories. The ratio of stimulated to fasting CBA expressed in a stimulation quotient did not rise in more advanced liver disease. These findings are best explained by a constant fractional clearance of bile acids by the liver. We conclude that the serum conjugated bile acid determination as a test of liver cell function is not sensitive enough to identify all cases of biopsy-proven liver disease. |
| Databáze: | OpenAIRE |
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