The impact of different doses of indocyanine green on the sentinel lymph-node mapping in early stage endometrial cancer
| Autor: | Maria Luisa Gasparri, Debora Verri, Andrea Papadia, Michael D. Mueller, Alessandro Buda, Giampaolo Di Martino, Beatrice Bussi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Indocyanine Green Cancer Research Multivariate analysis 610 Medicine & health 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Retrospective analysis Humans Medicine Stage (cooking) Laparoscopy Aged Neoplasm Staging Retrospective Studies Aged 80 and over 030219 obstetrics & reproductive medicine medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Endometrial cancer General Medicine Middle Aged Prognosis medicine.disease Endometrial Neoplasms body regions Sentinel lymph node mapping Oncology chemistry 030220 oncology & carcinogenesis Multivariate Analysis Female Sentinel Lymph Node Detection rate business Nuclear medicine Indocyanine green |
| Zdroj: | Papadia, Andrea; Buda, Alessandro; Gasparri, Maria Luisa; Di Martino, Giampaolo; Bussi, Beatrice; Verri, Debora; Mueller, Michael (2018). The impact of different doses of indocyanine green on the sentinel lymph-node mapping in early stage endometrial cancer. Journal of cancer research and clinical oncology, 144(11), pp. 2187-2191. Springer 10.1007/s00432-018-2716-3 |
| DOI: | 10.1007/s00432-018-2716-3 |
| Popis: | INTRODUCTION Aim of the study is to evaluate the impact of different doses of indocyanine green (ICG) on the sentinel lymph-node (SLN) mapping in endometrial cancer (EC). MATERIALS AND METHODS A retrospective analysis of EC patients undergoing a laparoscopic SLN mapping at two institutions was performed. Two different injection protocols were used (protocol # 1: 5 mg/ml and a volume of 8 ml; protocol # 2: 1.25 mg/ml and a volume of 4 ml). In every case, the injection was intracervical. The laparoscopic equipment adopted was the same among both institutions. Overall and bilateral detection rates (DR) and median number of retrieved SLNs were calculated. At uni- and multivariate analysis factors (including ICG dose) associated with DR and number of detected SLNs were investigated. RESULTS Overall, 168 patients were included. The overall and bilateral DR were 96.3 and 84.5%. Median number of removed SLNs was 3 (0-18). In 56% of the patients, a median number of 6 (1-93) non-SLNs (NSLNs) were removed. Seventeen (10.1%) patients had metastatic SLNs. At multivariate analysis, no factors were associated with bilateral DR. ICG dose was the only factor associated with number of removed SLNs at multivariate analysis. CONCLUSION A larger dose of ICG is associated with a higher number of retrieved SLNs but not with an increased bilateral DR. |
| Databáze: | OpenAIRE |
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