Altered Rolandic gamma-band activation associated with motor impairment and ictal network desynchronization in childhood epilepsy
| Autor: | Bill Chu, Elizabeth W. Pang, Amrita Viljoen, Rohit Sharma, Sam M. Doesburg, George M. Ibrahim, O Carter Snead, Mary Lou Smith, James T. Rutka |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Anatomy and Physiology Adolescent Neurophysiology lcsh:Medicine Motor Activity Developmental and Pediatric Neurology Electroencephalography Social and Behavioral Sciences Pediatrics Epilepsy Cortex (anatomy) medicine Humans Psychology Ictal Child lcsh:Science Biology Cerebral Cortex Motor Systems Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Magnetoencephalography Motor control medicine.disease Mental Health medicine.anatomical_structure Neurology Cerebral cortex Child Preschool Medicine Female lcsh:Q Nerve Net business Neuroscience Research Article Motor cortex |
| Zdroj: | PLoS ONE, Vol 8, Iss 1, p e54943 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Epilepsy is associated with an abnormal expression of neural oscillations and their synchronization across brain regions. Oscillatory brain activation and synchronization also play an important role in cognition, perception and motor control. Childhood epilepsy is associated with a variety of cognitive and motor deficits, but the relationship between altered functional brain responses in various frequency ranges and functional impairment in these children remains poorly understood. We investigated functional magnetoencephalographic (MEG) responses from motor cortex in multiple functionally relevant frequency bands following median nerve stimulation in twelve children with epilepsy, including four children with motor impairments. We demonstrated that children with motor impairments exhibit an excessive gamma-band response from Rolandic cortex, and that the magnitude of this Rolandic gamma response is negatively associated with motor function. Abnormal responses from motor cortex were also associated with ictal desynchronization of oscillations within Rolandic cortex measured using intracranial EEG (iEEG). These results provide the evidence that ictal disruption of motor networks is associated with an altered functional response from motor cortex, which is in turn associated with motor impairment. |
| Databáze: | OpenAIRE |
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