Soluble intercellular adhesion molecule-1 in paediatric connective tissue diseases
| Autor: | Susana A. Laucella, Vera Giraudi, E Gaddi, Jeanette Balbaryski, RJ Cuttica |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Adolescent medicine.drug_class Intercellular Adhesion Molecule-1 Arthritis Connective tissue Monoclonal antibody Severity of Illness Index medicine Humans Lupus Erythematosus Systemic Child ICAM-1 Lupus erythematosus Cell adhesion molecule business.industry General Medicine medicine.disease Arthritis Juvenile medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology Polyarthritis Female business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 88(4) |
| ISSN: | 0803-5253 |
| Popis: | The intercellular adhesion molecule-1 (ICAM-1) is a cytokine-induced glycoprotein involved in the recruitment of cells into tissues undergoing inflammatory responses. The aim of this study was to compare the levels of soluble ICAM-1 (s-ICAM-1) in children with juvenile chronic arthritis (JCA) and systemic lupus erythematosus (SLE) and to evaluate the usefulness of this molecule as marker of disease activity. Levels of s-ICAM-1 were measured in sera using a monoclonal antibody sandwich enzyme-linked immunoassay. Serum levels (mean+/-SD) of s-ICAM-1 in 37 children with JCA, 18 patients suffering from SLE and 25 healthy controls were 609+/-184, 513+/-139 and 210+/-95 ng/ml, respectively. A significant difference could be demonstrated between the levels of s-ICAM-1 in sera from each disease, as a group, and those of healthy controls. Higher levels of s-ICAM-1 were recorded in JCA patients with systemic features and patients who had polyarthritis than in children who were pauciarticular. A positive correlation was observed between s-ICAM-1 levels and disease activity score in SLE patients. Moreover, s-ICAM-1 levels closely followed clinical conditions in five children with SLE during follow-up. The data show that s-ICAM-1 levels are increased in children suffering from connective tissue diseases and reflect disease status or activity, suggesting the usefulness of this molecule in the follow-up of these diseases. |
| Databáze: | OpenAIRE |
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