DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

Autor: Arend Heerschap, Y.D. Reijmer, Laus M. Broersen, Katrien M. Brouwer, T. van Groen, Pieter J. Dederen, C.E.E.M. van der Zee, Amanda J. Kiliaan, Carlijn R. Hooijmans, Dieter Lütjohann
Rok vydání: 2009
Předmět:
Male
Aging
Pathology
Blood volume
Aetiology
screening and detection [ONCOL 5]
Neuroinformatics [DCN 3]
Alzheimer's Disease
Cholesterol
Dietary
Mice
chemistry.chemical_compound
Cerebral circulation
Cognition
0302 clinical medicine
Medicine
2. Zero hunger
0303 health sciences
Blood Volume
Behavior
Animal
Fatty Acids
Brain
Pathophysiology
3. Good health
Mitochondrial medicine [IGMD 8]
Cholesterol
Neurology
APPswe/PS1dE9 transgenic mice
Functional Neurogenomics [DCN 2]
MRI
medicine.medical_specialty
Docosahexaenoic Acids
Energy and redox metabolism [NCMLS 4]
Transgene
Mice
Transgenic
lcsh:RC321-571
03 medical and health sciences
Atrophy
Alzheimer Disease
Memory
Translational research [ONCOL 3]
mental disorders
Animals
Amyloid-β
Maze Learning
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
030304 developmental biology
Brain Chemistry
Amyloid beta-Peptides
business.industry
Cerebral blood volume
Metabolism
Tissue engineering and pathology [NCMLS 3]
medicine.disease
Diet
nervous system diseases
Disease Models
Animal
chemistry
business
030217 neurology & neurosurgery
Zdroj: Neurobiology of Disease, Vol 33, Iss 3, Pp 482-498 (2009)
Neurobiology of Disease, 33, 482-98
Neurobiology of Disease, 33, 3, pp. 482-98
ISSN: 0969-9961
Popis: Contains fulltext : 79884.pdf (Publisher’s version ) (Closed access) Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Abeta metabolism indirectly via the vasculature. We investigated whether DHA-enriched diets or cholesterol-containing Typical Western Diets (TWD) alter behavior and cognition, cerebral hemodynamics (relative cerebral blood volume (rCBV)) and Abeta deposition in 8- and 15-month-old APP(swe)/PS1(dE9) mice. In addition we investigated whether changes in rCBV precede changes in Abeta deposition or vice versa. Mice were fed regular rodent chow, a TWD-, or a DHA-containing diet. Behavior, learning and memory were investigated, and rCBV was measured using contrast-enhanced MRI. The Abeta load was visualized immunohistochemically. We demonstrate that DHA altered rCBV in 8-month-old APP/PS1 and wild type mice[AU1]. In 15-month-old APP/PS1 mice DHA supplementation improved spatial memory, decreased Abeta deposition and slightly increased rCBV, indicating that a DHA-enriched diet can diminish AD-like pathology. In contrast, TWD diets decreased rCBV in 15-month-old mice. The present data indicate that long-term dietary interventions change AD-like pathology in APP/PS1 mice. Additionally, effects of the tested diets on vascular parameters were observed before effects on Abeta load were noted. These data underline the importance of vascular factors in the APP/PS1 mouse model of AD pathology.
Databáze: OpenAIRE
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