Pretransplantation Blood Transfusion Revisited
| Autor: | C. J. M. Melief, E. van Twuyver, J. M. Wilmink, I. J. M. ten Berge, R. J. D. Mooijaart, L. P. de Waal, A. R. van der Horst, Wybe Martin Kast |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 1991 |
| Předmět: |
Kidney
medicine.medical_specialty Blood transfusion business.industry medicine.medical_treatment General Medicine Human leukocyte antigen medicine.disease Organ transplantation Histocompatibility medicine.anatomical_structure Antigen Immunology Cytotoxic T cell Medicine business Kidney transplantation |
| Zdroj: | New England journal of medicine, 325(17), 1210-1213. Massachussetts Medical Society |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | BACKGROUND: Blood transfusion before organ transplantation has a beneficial effect on allograft survival; the mechanism of this effect has remained a mystery. In murine models, the presence of common histocompatibility antigens in the blood donor and the recipient favors the induction of allograft tolerance. METHODS: To investigate the effect of HLA compatibility between blood donor and recipient on the induction of allograft tolerance, we determined the relative frequency of cytotoxic T-lymphocyte precursors specific for donor cells before and at several times after blood transfusion in 23 patients awaiting a first renal transplant. We correlated the results with the presence of shared HLA antigens. RESULTS: T-cell nonresponsiveness against donor cells developed after blood transfusion in 10 of the 23 patients. Tolerance developed only if the blood donor and the recipient had one HLA haplotype or at least one HLA-B and one HLA-DR antigen in common (as was observed in 9 of these 10 patients). Tolerance developed relatively late after blood transfusion (one to two months) and was long-lasting. No decline in the T-cell response against donor alloantigens was observed in any of the 13 patients who received transfusions without having HLA-antigen compatibility with the donor. CONCLUSIONS: Blood transfusion in which there is a common HLA haplotype or shared HLA-B and HLA-DR antigens induces tolerance to donor antigens. This finding may lead to the development of new strategies with which to induce tolerance for transplantation after blood transfusion. Perhaps transplant donors will be selected not only by HLA-antigen matching, but also on the basis of acceptable HLA-antigen mismatches associated with T-cell non-responsiveness induced by selected blood transfusion |
| Databáze: | OpenAIRE |
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