Age-Related Uterotrophic Response of Soy Isoflavone Intake in Rats
Autor: | Sun-Hee Kim, Hae-Kyung Nam, Na-Hye Myong, Moon-Jeong Chang |
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Rok vydání: | 2007 |
Předmět: |
Aging
medicine.medical_specialty Urinary system Biological Availability Medicine (miscellaneous) Genistein Phytoestrogens Rats Sprague-Dawley Eating chemistry.chemical_compound Urinary excretion Internal medicine Age related Animals Medicine Juvenile SOY ISOFLAVONES Nutrition and Dietetics business.industry Body Weight Uterus Daidzein food and beverages Isoflavones Diet Rats Endocrinology chemistry Female Soybeans business |
Zdroj: | Journal of Medicinal Food. 10:300-307 |
ISSN: | 1557-7600 1096-620X |
DOI: | 10.1089/jmf.2006.018 |
Popis: | This study investigated the effects of soy isoflavone intake on uterotrophic responses in growing (juvenile) and adult female rats. In the growing rats, feed intake showed a decreasing trend as the level of dietary isoflavones increased to 0.02%, 0.1%, and 0.2% of the diets. However, in the case of the adult rats there were no significant differences among groups. Weight gains were significantly lower in the rats fed 0.1% and 0.2% isoflavones than the controls in both juvenile and adult rats. The urinary excretion of daidzein and genistein was significantly increased with increasing levels of dietary isoflavones. The calculated urinary recoveries of daidzein and genistein were significantly lower in the groups fed 0.1% and 0.2% isoflavones compared to the juvenile and adult rat groups fed 0.02% isoflavones; no significant difference was observed between the 0.1% and 0.2% groups. The calculated urinary recoveries of daidzein and genistein in the adult rats were significantly higher than in the juvenile rats. The differences in the urinary recoveries between ages may be due to greater availability of the isoflavones in the adult rats. Isoflavone supplementation did not alter the histological phenotype of endometrial cells in growing rats, but a hyperplastic response of endometrium was shown in the adult rats. Dietary isoflavones, therefore, may not have an estrogenic effect on the uterus at these dose levels during the growth period, but this organ would be expected to be a likely target for isoflavone action in adults. We observed in the present study that isoflavones are more bioavailable in adult rats than in the juvenile rats. Therefore, soy isoflavone supplementation may not act as an endocrine disrupter during the growth period but may exert a phytoestrogenic effect on the uterus of adult rats. |
Databáze: | OpenAIRE |
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