Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice
| Autor: | Angela Dake, Chris Eckman, James Meiners, George A. Carlson, Karen K. Hsiao, Steven P. Nilsen, David R. Borchelt, Sherry Turner, J. Douglas Coffin, Steven G. Younkin, Valerie Danielson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Genetically modified mouse
Apolipoprotein E Transgene BACE1-AS Gene Expression Mice Transgenic Biology Amyloid beta-Protein Precursor Mice Apolipoproteins E mental disorders Gene expression Genetics medicine Amyloid precursor protein Animals Senile plaques Molecular Biology Genetics (clinical) Alleles Mice Inbred C3H Superoxide Dismutase General Medicine medicine.disease Cell biology Mice Inbred C57BL Phenotype biology.protein Fibroblast Growth Factor 2 Genes Lethal Alzheimer's disease Protein Processing Post-Translational Gene Deletion |
| Zdroj: | Human molecular genetics. 6(11) |
| ISSN: | 0964-6906 |
| Popis: | Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice depending on the genetic background. For example, concentrations of APP that produce amyloid plaques in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J mice. Expression of SOD1 transgenes is protective, suggesting involvement of oxidative damage in premature death, but ablation of Apoe had no significant effect. In contrast, FGF2 transgene overexpression enhances the lethal effects of APP. Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|