Bone mineral deficits in recipients of hematopoietic cell transplantation: the impact of young age at transplant
| Autor: | Lei Zhang, Anna Petryk, Julia Steinberger, Donald R. Dengel, Lynda E. Polgreen, Paul A. Hoffmeister, K. S. Baker, James S. Hodges |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning Adolescent Bone density bone marrow transplantation medicine.medical_treatment Osteoporosis lean body mass Hematopoietic stem cell transplantation Article DXA scan Young Adult Absorptiometry Photon children Bone Density Risk Factors Internal medicine medicine Humans Young adult Risk factor Child Femoral neck Bone mineral Transplantation business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease osteoporosis Surgery Bone Diseases Metabolic surgical procedures operative medicine.anatomical_structure Female bone mineral density business |
| Zdroj: | Bone marrow transplantation |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | Low bone mineral density (BMD) has been reported in recipients of pediatric hematopoietic cell transplantation (HCT), but it is unclear whether age at HCT has a role. The objective of this cross-sectional study was to determine if patients treated with HCT before the age of 10 years have long-term BMD deficits compared with patients transplanted at an older age and with sibling controls. The study included 151 HCT recipients (87 males), age at study 24.7±8.6 years treated with HCT for hematologic malignancies at age 10.9±6.4 years, and 92 healthy sibling controls (49 males), age at study 22.3±8.0 years. Dual-energy x-ray absorptiometry was performed to measure BMD Z-scores for total body BMD (TBMD), lumbar spine BMD (LBMD) and femoral neck BMD (FNBMD, for subjects 20 years at study visit). Patients10 years at HCT had significantly lower TBMD and FNBMD Z-scores (by 0.5 and 0.8 s.d., respectively) compared with controls (P=0.003 and P=0.0001, respectively) and patients18 years at HCT (P=0.04 and P=0.004, respectively) at an average of 14 years after HCT. In conclusion, this study identified young age at transplant as an important risk factor for bone deficits in young adulthood, suggesting that efforts to reduce bone loss should focus on this patient population. |
| Databáze: | OpenAIRE |
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