The study of the combination detection of HPV-DNA and p16INK4a in cervical lesions
| Autor: | Xiao-Man Jiang, Shuang Huang, Xin-Min Nie, Min-Zhu Huang, Deng-Qing Li, Hong-Bo Li |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Adolescent Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Gastroenterology Young Adult Internal medicine Biomarkers Tumor Carcinoma Humans Medicine Papillomaviridae neoplasms Rank correlation Receiver operating characteristic business.industry Genes p16 Hybrid capture Absolute risk reduction Positive interaction Hematology General Medicine Middle Aged medicine.disease Hpv testing Oncology DNA Viral Female business Protein Binding |
| Zdroj: | Medical Oncology. 28:547-552 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-010-9705-y |
| Popis: | The objective of this study is to detect the infection of human papillomavirus (HPV) and the expression of p16INK4a in cervical lesions and to investigate the interaction between hrHPV and p16INK4a for cervical lesions and its diagnostic efficiency. hrHPV-DNA was detected by the hybrid capture II (HC-II) system. Immunochemical method was used to detect the expression of p16INK4a, and histopathologic test was performed to identify cervical lesions. χ 2 test and Spearman’s rank correlation were used for statistical analysis. Additive effects model was used to analyze the interaction. The diagnostic sensitivity, specificity, positive predictive values, negative predictive values, accuracy, and the area under the receiver operating characteristic curve were calculated with SPSS 13.0. hrHPV and p16INK4a positive rate increased (P |
| Databáze: | OpenAIRE |
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