Trans-catheter arterial chemoembolisation for hepatocellular carcinoma in patients with viral cirrhosis: role of combined staging systems, Cancer Liver Italian Program (CLIP) and Model for End-stage Liver Disease (MELD), in predicting outcome after treatm

Autor:	Edoardo G. Giannini, Domenico Risso, Simone Polegato, Bruno Chiarbonello, Alessandra Fumagalli, Elena Podestà, G. De Caro, Emanuela Testa, Paola Romagnoli, Roberto Testa, Federica Botta, Federica Malfatti, G. Cittadini
Rok vydání:	2003
Předmět:	Adult Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Palliative care Gastroenterology Liver disease Model for End-Stage Liver Disease Internal medicine medicine Carcinoma Humans Pharmacology (medical) Chemoembolization Therapeutic Survival analysis Aged Neoplasm Staging Aged 80 and over Hepatology business.industry Liver Neoplasms Palliative Care Cancer Middle Aged medicine.disease Survival Analysis body regions Treatment Outcome Hepatocellular carcinoma Female business Liver Failure
Zdroj:	Alimentary Pharmacology & Therapeutics. 17:1563-1569
ISSN:	0269-2813
Popis:	Summary Background: Trans-catheter arterial chemoembolisation (TACE) is the most common palliative treatment for hepatocellular carcinoma (HCC). The therapeutic options depend both on the characteristics of the tumour and on functional staging of the cirrhosis. Aim: To evaluate the effects of TACE on the survival of cirrhotic patients with HCC according to different staging systems [Okuda score, Cancer Liver Italian Program (CLIP) score, Model for End-stage Liver Disease (MELD) score] and in relation to the side-effects of TACE. Methods: Fifty cirrhotic patients, 36 CTP class A and 14 class B, underwent 106 TACE treatments with mitoxantrone. Survival at 12, 24, and 36 months was evaluated. Results: MELD at 12 months and CLIP at 24 months were identified as significant variables associated with survival. Combined cut-offs of CLIP and of MELD identified four subgroups of patients with different survivals, at 12, 24 and 36 months, respectively: CLIP ≥ 2 and MELD ≥ 10 (63%, 20% and 0%), CLIP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ce630a8791438f9b2e1a5aacfddfd8 https://doi.org/10.1046/j.1365-2036.2003.01647.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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