The evaluation of mutagenic potential of some dental cements in used dentistry with salmonella Ames Microsome test and SOS chromotest

Autor: Baran Dadakoğlu, Ebru Yılmaz, Güven Uraz
Rok vydání: 2013
Předmět:
Zdroj: Current Opinion in Biotechnology. 24:S99
ISSN: 0958-1669
DOI: 10.1016/j.copbio.2013.05.298
Popis: mediate some of the genetic influence on normal skeletal growth and thus influence osteoporosis risk. The aim of the present study was to examine possible associations of T34C polymorphism in the CYP17 gene with femoral (F-BMD), spinal BMD (S-BMD), as well as circulating alkaline phosphatase (ALP), osteocalcin (OC; formation markers), beta-CrossLaps (CTx; resorption marker) in 350 Slovak postmenopausal women (62.26±0.44 years).Womenwere selected according to strict inclusion criteria. Genetic polymorphism was detected by PCR-RFLP method. Genotype frequencies and frequencies of fractures were tested using the chi-square test. The differences of quantitative variables between the genotypes were analyzed by covariance analysis (GLM procedure) after correction of the measurements for age and BMI. The prevalence of each genotypewas 30.9%, 49.0%, and 19.7% for TT, TC, and CC genotypes, respectively. No significant effect of the T34C polymorphism was recorded on femoral and spinal BMD, as well as on biochemical bone turnover markers in the tested population. However; heterozygous TC individuals had tendency to insignificantly lower F-BMD and S-BMD values with increasing OC and CTx concentrations which could indicate increased bone remodeling rate in this genotype group. The results can contribute tomore detailed insight into the genetics of osteoporosis with respect to a population of Slovak postmenopausal women. Acknowledgement: The study was supported by the grant KEGA 035UKF-4/2013.
Databáze: OpenAIRE
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