Discovery of a novel, potent and selective human β3-adrenergic receptor agonist

Autor:	Yasuyo Tomishima, Kenichi Washizuka, Masayuki Kato, Hitoshi Hamashima, Yutaka Nakajima, Toshiko Miura, Hiroshi Kayakiri, Emiko Imamura, Hiroaki Ohtake
Rok vydání:	2005
Předmět:	Agonist medicine.drug_class Clinical Biochemistry Pharmaceutical Science Adrenergic beta-3 Receptor Agonists CHO Cells Biochemistry Chemical synthesis Structure-Activity Relationship Pharmacokinetics In vivo Cricetinae Drug Discovery medicine Animals Humans Receptor Molecular Biology β3 adrenergic receptor Chemistry Organic Chemistry Adrenergic beta-Agonists In vitro Models Chemical Molecular Medicine Selectivity
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:251-254
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2004.11.001
Popis:	The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good β3-AR activity and selectivity, was identified and pharmacokinetics were investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cba7b3143ff5d369186e60ac75f43d https://doi.org/10.1016/j.bmcl.2004.11.001 Zobrazit plný text záznamu Full Text from ScienceDirect