ENZYMIC CONVERSION OF 3-HYDROXYANTHRANILIC ACID INTO CINNABARINIC ACID BY THE NUCLEAR FRACTION OF RAT LIVER
| Autor: | Subbarao Pv, Jegannathan Ns, Vaidyanathan Cs |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Silver
Stereochemistry Iron General Mathematics 3-Hydroxyanthranilic Acid Benzoates Arsenicals chemistry.chemical_compound Oxazines Anthranilic acid ortho-Aminobenzoates Cysteine Enzyme Inhibitors 3-Hydroxyanthranilic acid Cell Nucleus Molybdenum Pharmacology chemistry.chemical_classification biology Research Applied Mathematics Articles Mercury Glutathione Metabolism biology.organism_classification Rats Enzyme Liver chemistry Biochemistry Hydroxymercuribenzoates Spinach Liver function Oxidoreductases Copper |
| Zdroj: | Biochemical Journal. 95:628-632 |
| ISSN: | 0006-2936 |
| DOI: | 10.1042/bj0950628 |
| Popis: | Although several authors have implicated 3-hydroxyanthranilic acid (3-OHA) as an intermediate in tryptophaniacin pathway in animals (Kaplan, 1961), alternative pathways of metabolism of this compound have not been fully explored. Madhusudanan Nair obtained an enzyme from spinach leaves which could convert 3-OHA to cinnabarinic acid (private communication). Viollier and Sullmann (1950) reported the conversion of 3-OHA to an unidentified red compound by rat liver homogenates. The present investigation describes the identification of this product as cinnabarinic acid (2-amino-3-H-isophenoxazine-3-one-1,9-dicarboxylic acid). Cinnabarinic acid is known to occur in nature along with cinnabarin is olated from the fungus Polystictus sanguineus (Gripenberg et al., 1957; Gripenberg, 1958). |
| Databáze: | OpenAIRE |
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