Hybrid dual mode sensor for simultaneous detection of two serum metabolites
| Autor: | David R. S. Cumming, Boon Chong Cheah, Chunxiao Hu, Mohammed A. Al-Rawhani, Srinivas Velugotla |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemistry 010401 analytical chemistry Ion sensitive Dual mode Mass spectrometry 01 natural sciences 0104 chemical sciences Photodiode law.invention 03 medical and health sciences 030104 developmental biology Human disease law Serum glucose Metabolome Electrical and Electronic Engineering Metabolic disease Biological system Instrumentation |
| ISSN: | 1530-437X |
| Popis: | Metabolites are the ultimate readout of disease phenotype that plays a significant role in the study of human disease. Multiple metabolites sometimes serve as biomarkers for a single metabolic disease. Therefore, simultaneous detection and analysis of those metabolites facilitate early diagnostics of the disease. Conventional approaches to detect and quantify metabolites include mass spectrometry and nuclear magnetic resonance that require bulky and expensive equipment. Here, we present a disposable sensing platform that is based on complementary metal–oxide–semiconductor process. It contains two sensors: an ion sensitive field-effect transistor and photodiode that can work independently for detection of pH and color change produced during the metabolite-enzyme reaction. Serum glucose and cholesterol have been detected and quantified simultaneously with the new platform, which shows good sensitivity within the physiological range. Low cost and easy manipulation make our device a prime candidate for personal metabolome sensing diagnostics. |
| Databáze: | OpenAIRE |
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