Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice
| Autor: | Jean-Jacques Pocidalo, Yves Cohen, Jean-Louis Vildé, L Struillou, N Lounis, C Perronne, J Grosset, Guylène Bertrand |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
C57BL/6
medicine.drug_class Antibiotics Microbiology Mice Oral administration In vivo Clarithromycin polycyclic compounds medicine Animals Humans Tuberculosis Pharmacology (medical) Antibacterial agent Pharmacology Roxithromycin biology Macrophages organic chemicals bacterial infections and mycoses biology.organism_classification Mice Inbred C57BL Infectious Diseases Female Mycobacterium avium Research Article medicine.drug Mycobacterium |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 39:878-881 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | The activity of roxithromycin against three clinical isolates of Mycobacterium avium was compared with that of clarithromycin both in a model of infection of human monocyte-derived macrophages and in a model of established infection of C57BL/6 mice. In the cell culture model, roxithromycin and clarithromycin were bactericidal for strains MO-1 and N-92159 and bacteriostatic for strain N-93043. For the three strains, the differences between the intracellular activities of roxithromycin and clarithromycin were not singificant after 7 days of treatment. Mice were infected with the MO-1 strain. Drugs were given by gavage at a dosage of 200 mg/kg of body weight 6 days per week for 16 weeks starting 5 weeks after infection. At the end of treatment, clarithromycin was more effective than roxithromycin in lungs; roxithromycin was as effective as clarithromycin in spleens. Thus, the activity of roxithromycin was comparable to that of clarithromycin both in vitro and in vivo. |
| Databáze: | OpenAIRE |
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