Acute monocytic leukemia with a novel 10;11 rearrangement resolved by fluorescence in situ hybridization
| Autor: | Sanjeev Jalihal, Ann E. Watmore, Elizabeth J Sinclair |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Centromere Chromosomal translocation Locus (genetics) Biology Translocation Genetic Chromosome Painting hemic and lymphatic diseases Proto-Oncogenes Genetics medicine Humans Acute monocytic leukemia Molecular Biology medicine.diagnostic_test Chromosomes Human Pair 10 Chromosomes Human Pair 11 Cytogenetics Chromosome Gene rearrangement Histone-Lysine N-Methyltransferase medicine.disease Molecular biology DNA-Binding Proteins Karyotyping Chromosome Inversion Leukemia Monocytic Acute Monocytic leukemia Female DNA Probes Myeloid-Lymphoid Leukemia Protein Fluorescence in situ hybridization Transcription Factors |
| Zdroj: | Cancer genetics and cytogenetics. 118(1) |
| ISSN: | 0165-4608 |
| Popis: | Fluorescence in situ hybridization analysis in an adult with acute monocytic leukemia revealed the complex nature of a rearrangement between chromosomes 10 and 11, which resulted in disruption of the MLL gene. Using a combination of chromosome 10 and 11 paints, a 10 centromere-specific sequence, and a probe for the MLL locus at 11q23, the rearrangement was deduced to have involved a reciprocal translocation between chromosomes 10 and 11, followed by an inversion within the short arm of the derivative 10. To our knowledge, this novel rearrangement has not been described previously. |
| Databáze: | OpenAIRE |
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