Long-term survival in severe combined immune deficiency: The role of persistent maternal engraftment

Autor:	Fügen Ersoy, Francois Le Deist, Tuba Turul, Geneviève de Saint Basile, S. Caillat-Zucmann, Ozden Sanal, Ilhan Tezcan, Duygu Uckan, Sevim Balci, Marguerite Prieur, Gönül Hiçsönmez
Rok vydání:	2005
Předmět:	Male medicine.medical_specialty animal diseases chemical and pharmacologic phenomena macromolecular substances Gene mutation Competence (law) Immune system Long term survival medicine Humans In patient Child business.industry Critically ill Janus Kinase 3 Protein-Tyrosine Kinases biochemical phenomena metabolism and nutrition medicine.disease Pedigree Surgery Survival Rate Graft-versus-host disease Pediatrics Perinatology and Child Health Immunology bacteria Severe Combined Immunodeficiency business Immunity Maternally-Acquired
Zdroj:	The Journal of Pediatrics. 146:137-140
ISSN:	0022-3476
DOI:	10.1016/j.jpeds.2004.09.010
Popis:	Two siblings with severe combined immune deficiency, one with maternal engraftment and detectable immunologic functions who was alive at the age of 8 years are presented. Both patients had the same JAK3 gene mutation, suggesting that maternal engraftment may result in immune competence leading to long-term survival in patients with severe combined immune deficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c710974b31a3890c0fb5b96a6016d7 https://doi.org/10.1016/j.jpeds.2004.09.010 Zobrazit plný text záznamu Full Text from ScienceDirect