Ageing Effects on 3-Dimensional Femoral Neck Cross-Sectional Asymmetry: Implications for Age-Related Bone Fragility in Falling
| Autor: | Richard L. Prince, Benjamin C.C. Khoo, Egon Perilli, Joshua R. Lewis, Keenan Brown |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Aging Endocrinology Diabetes and Metabolism medicine.medical_treatment media_common.quotation_subject 030209 endocrinology & metabolism Asymmetry 03 medical and health sciences Young Adult 0302 clinical medicine Imaging Three-Dimensional Bone Density medicine Cortical Bone Humans Radiology Nuclear Medicine and imaging Orthopedics and Sports Medicine Quantitative computed tomography Reduction (orthopedic surgery) Osteoporosis Postmenopausal media_common Femoral neck Aged Orthodontics Bone mineral Aged 80 and over medicine.diagnostic_test business.industry Femur Neck Organ Size Middle Aged Femoral Neck Fractures medicine.anatomical_structure Ageing Cancellous Bone Cortical bone Accidental Falls Female 030101 anatomy & morphology Falling (sensation) business Tomography X-Ray Computed |
| Zdroj: | Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 22(2) |
| ISSN: | 1094-6950 |
| Popis: | This paper explores the effects of aging on femoral neck (FN) anatomy in a study of women aged 20-90years in relation to implications for FN fracture propensity in buckling. Five hundred and four participants were scanned by Quantitative Computed Tomography and analyzed using Quantitative Computed Tomography Pro BIT (Mindways). FN cross-section was split through geometric center into superior and inferior sectors. Bone mass, structural measurements, and bone mineral density were analyzed. Buckling ratio was calculated as ratio of buckling radius to cortical thickness. Between 2nd decade and 8th decade, age-related integral bone mass reduction in superior sector was substantially larger than in inferior sector (33% compared to 21%), especially in cortical bone superiorly compared to inferiorly (53% vs 21%; p < 0.001), principally due to reduction in cortical thickness, averaged cortical thickness (56%) with little difference in density. Superior and inferior sector trabecular bone mineral density reduction was similar at 41% and 43% respectively. Differential cortical bone loss in superior sector resulted in a 59% inferior displacement (δ) of center-of-mass from geometric center. Differences in δ and averaged cortical thickness with age accounted for a 151% increase in mean superior buckling ratio from 9 to 23. Analysis confirms significant progressive age-related superior cortical bone loss as the major age effect on FN structure with relative preservation of inferior cortex probably related to maintenance of inferior sector by regular loading as a result of standing and walking. Computation of buckling ratio may allow prediction of fracture propensity in a sideways fall. |
| Databáze: | OpenAIRE |
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