Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet
| Autor: | Korbinian Löbmann, Christel A. S. Bergström, Nele-Johanna Hempel, Padryk Merkl, Shno Asad, Ragna Berthelsen, Georgios A. Sotiriou, Alexandra Teleki, Matthias Manne Knopp |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Drug Compounding Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences Excipients Drug Discovery medicine Irradiation Solubility Dissolution chemistry.chemical_classification Plasmonic nanoparticles Polyvinylpyrrolidone Lasers Povidone Polymer Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences Amorphous solid chemistry Chemical engineering Celecoxib Nanoparticles Molecular Medicine 0210 nano-technology Tablets medicine.drug |
| Zdroj: | Molecular Pharmaceutics. 18:2254-2262 |
| ISSN: | 1543-8392 1543-8384 |
| Popis: | Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. During on-demand drug amorphization, the drug molecularly disperses into a polymer to form an amorphous solid at elevated temperatures inside a tablet. This study investigates, for the first time, the utilization of photothermal plasmonic nanoparticles for on-demand drug amorphization as a new pharmaceutical application. For this, near-IR photothermal plasmonic nanoparticles were tableted together with a crystalline drug (celecoxib) and a polymer (polyvinylpyrrolidone). The tablets were subjected to a near-IR laser at different intensities and durations to study the rate of drug amorphization under each condition. During laser irradiation, the plasmonic nanoparticles homogeneously heated the tablet. The temperature was directly related to the rate and degree of amorphization. Exposure times as low as 180 s at 1.12 W cm-2 laser intensity with only 0.25 wt % plasmonic nanoparticles and up to 50 wt % drug load resulted in complete drug amorphization. Therefore, near-IR photothermal plasmonic nanoparticles are promising excipients for on-demand drug amorphization with laser irradiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|