Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria
| Autor: | Inge Verschraegen, Jan Verhaegen, Denis Pierard, Kristof Vandoorslaer, Marijke Reynders, Geert Claeys, Sabine Lauwers, Ingrid Wybo, Margaretha Ieven, B. Gordts, Marc Struelens, Pierrette Melin, Michel Delmée, Youri Glupczynski |
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| Přispěvatelé: | Supporting clinical sciences, Microbiology and Infection Control, Clinical Biology, Faculty of Medicine and Pharmacy, Diabetes Pathology & Therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Bacterial Infections/microbiology Bacteria Anaerobic/drug effects Microbial Sensitivity Tests Biology Tazobactam Anti-Bacterial Agents/pharmacology Microbiology Hospitals University Bacteria Anaerobic Belgium Moxifloxacin Drug Resistance Bacterial medicine Prevalence Humans Pharmacology (medical) Etest Antibacterial agent Original Research Pharmacology Pharmacology. Therapy Clindamycin anaerobes Bacterial Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Piperacillin/tazobactam surveillance Human medicine Anaerobic bacteria medicine.drug Piperacillin |
| Zdroj: | Journal of Antimicrobial Chemotherapy The journal of antimicrobial chemotherapy |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies. Methods: Four hundred and three strict anaerobic clinical isolates were prospectively collected from February 2011 to April 2012 in eight Belgian university hospitals. MICs were determined by one central laboratory for 11 antimicrobial agents using Etest methodology. Results: According to EUCAST breakpoints, >90% of isolates were susceptible to amoxicillin/clavulanate (94%), piperacillin/tazobactam (91%), meropenem (96%), metronidazole (92%) and chloramphenicol (98%), but only 70% and 40% to clindamycin and penicillin, respectively. At CLSI recommended breakpoints, only 71% were susceptible to moxifloxacin and 79% to cefoxitin. MIC50/MIC90 values for linezolid and for tigecycline were 1/4 and 0.5/4 mg/L, respectively. When compared with survey data from 2004, no major differences in susceptibility profiles were noticed. However, the susceptibility of Prevotella spp. and other Gram-negative bacilli to clindamycin decreased from 91% in 1993-94 and 82% in 2004 to 69% in this survey. Furthermore, the susceptibility of clostridia to moxifloxacin decreased from 88% in 2004 to 66% in 2011-12 and that of fusobacteria from 90% to 71%. Conclusions: Compared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy. |
| Databáze: | OpenAIRE |
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