Estimation of Potassium Changes Following Potassium Supplements in Hypokalemic Critically Ill Adult Patients–A Patient Personalized Practical Treatment Formula

Autor:	Yair Binyamin, Adir Israeli, Alexander Zlotnik, Victor Novack, Adi Segal, Amit Frenkel, Moti Klein, Lior Hassan
Rok vydání:	2021
Předmět:	endocrine system diseases Hyperkalemia Dose Potassium medicine.medical_treatment Population 030232 urology & nephrology chemistry.chemical_element 030204 cardiovascular system & hematology formula intensive care unit Article law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law hypokalemia medicine education Mechanical ventilation Creatinine education.field_of_study business.industry potassium nutritional and metabolic diseases General Medicine Intensive care unit Hypokalemia chemistry Anesthesia Medicine medicine.symptom business
Zdroj:	Journal of Clinical Medicine Volume 10 Issue 9 Journal of Clinical Medicine, Vol 10, Iss 1986, p 1986 (2021)
ISSN:	2077-0383
DOI:	10.3390/jcm10091986
Popis:	Hypokalemia is common among critically ill patients. Parenteral correction of hyperkalemia depends on dosages and patient characteristics. Our aims were to assess changes in potassium levels following parenteral administration, and to derive a formula for predicting rises in serum potassium based on patient characteristics. We conducted a population-based retrospective cohort study of adults hospitalized in a general intensive care unit for 24 h or more between December 2006 and December 2017, with hypokalemia. The primary exposures were absolute cumulative intravenous doses of 20, 40, 60 or 80 mEq potassium supplement. Adjusted linear mixed models were used to estimate changes in serum potassium. Of 683 patients, 422 had mild and 261 moderate hypokalemia (serum potassium 3.0–3.5 mEq/L and 2.5–2.99 mEq, respectively). Following doses of 20–80 mEq potassium, serum potassium levels rose by a mean 0.27 (±0.4) mEq/L and 0.45 (±0.54) mEq/L in patients with mild and moderate hypokalemia, respectively. Changes were associated with creatinine level, and the use of mechanical ventilation and vasopressors. Among critically ill patients with mild to moderate hypokalemia, increases in serum potassium after intravenous potassium supplement are influenced by several clinical parameters. We generated a formula to predict the expected rise in serum potassium based on clinical parameters.
Databáze:	OpenAIRE
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