Cytotoxic effects of sinococuline
| Autor: | Chun-Tao Che, Xian-Kai Wang, W.K. Liu |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Lipopolysaccharides
Cancer Research Programmed cell death Cell Survival Apoptosis HL-60 Cells Biology Cell Line Mice L Cells Leucine Macrophages Alveolar Tumor Cells Cultured Animals Humans Cytotoxic T cell Cytotoxicity Uridine Cells Cultured Plants Medicinal Dose-Response Relationship Drug Tumor Necrosis Factor-alpha Aknadinine Fibroblasts Antineoplastic Agents Phytogenic Molecular biology Rats Kinetics Morphinans Oncology Cell culture Immunology Alveolar macrophage Tumor necrosis factor alpha Thymidine |
| Zdroj: | Cancer Letters. 99:217-224 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(95)04065-x |
| Popis: | Three alkaloids, aknadinine, 1-nitroaknadinine and sinococuline, isolated from Stephania sutchuenensis were studied for their effects on a fibroblast cell line, eight tumor cell lines and a rat alveolar macrophage culture. Sinococuline is an effective tumor cell growth inhibitor whereas the toxicity of aknadinine and 1-nitroaknadinine towards all tested cells is low. A dose-dependent decrease in cell viability and in the uptake of tritiated-thymidine, -leucine and -uridine by these cells was observed when they were grown in the presence of sinococuline for 24 h. Exposure to sinococuline in vitro also altered the macrophage function by reducing the production of tumor necrosis factor and reactive nitrogen intermediates. Human leukaemic HL60 cells and mouse fibroblast L929 cells were used to study the underlying mechanism of cytotoxicity and apoptosis seem to be the mode of death induced by sinococuline |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect