A clinical pharmacologic study of chemotherapy and x-ray therapy in lung cancer
| Autor: | Sherwood P. Miller, Albert H. Owens, Clyde O. Brindley, Margarida M. Dederick, Bruce I. Shnider, James F. Holland, Thomas C. Hall, Kenneth B. Olson, Emil Frei, Thomas C. Chalmers, Charles Ross, John J. Lynch, Henry F. Hosley, Melvin J. Krant, C.Ronald Koons, Seymour Brenner |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Pathology Lung Neoplasms medicine.medical_treatment Gastroenterology X-Ray Therapy Internal medicine Carcinoma medicine Humans Neoplasm Metastasis Radiometry Lung cancer Chemotherapy Lung Radiotherapy business.industry General Medicine medicine.disease Radiation therapy Regimen medicine.anatomical_structure Toxicity Dactinomycin Fluorouracil business |
| Zdroj: | The American Journal of Medicine. 43:186-193 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(67)90163-5 |
| Popis: | Actinomycin D and 5-fluorouracil, given with x-ray in a dosage regimen sufficient to produce definite but tolerable gastrointestinal and marrow toxicity, did not increase the percentage of patients with carcinoma of the lung showing shrinkage of lesions in the irradiated field. There was no evidence of a more rapid onset of shrinkage of the tumor or of an additive effect at subtotal doses of x-ray. Patient survival was not affected beneficially by the addition of the chemotherapeutic agents. Toxicity was not correlated with responses induced. Patients classified as responders to therapy lived longer than those classified as nonresponders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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