Minimum antibiotic levels for selecting a resistance plasmid in a gnotobiotic animal model
| Autor: | Florence Corpet, Denis E. Corpet, Solange Lumeau |
|---|---|
| Přispěvatelé: | Xénobiotiques, Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE) |
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
minimum antibiotic concentration
Mouse MESH: Drug Resistance Microbial Antibiotics gnotobiotic mice Feces Mice residues Mathematical model Plasmid Ampicillin germfree resistant bacteria Pharmacology (medical) MESH: Animals colistin MESH: Models Theoretical Gentamicin Risk assessment Flumequin 0303 health sciences MESH: Microbial Sensitivity Tests MESH: R Factors MESH: Escherichia coli Minimum selecting concentration Gnotobiotic mice risk assessment MESH: Feces Drug Resistance Microbial Residues Anti-Bacterial Agents 3. Good health in vivo Infectious Diseases Streptomycin R plasmid Resistant bacteria Research Article medicine.drug veterinary treatment Veterinary treatment mice streptomycin Tetracycline medicine.drug_class R Factors selection [SDV.CAN]Life Sciences [q-bio]/Cancer Microbial Sensitivity Tests Biology gentamicin Microbiology 03 medical and health sciences flumequin MESH: Anti-Bacterial Agents MESH: Germ-Free Life In vivo medicine Escherichia coli Animals Germ-Free Life Animal model Germfree Selection MESH: Mice mouse 030304 developmental biology tetracycline Pharmacology Bactériologie Colistin 030306 microbiology animal model food Models Theoretical biology.organism_classification minimum selecting concentration Food Antimicrobial Agents ampicillin Minimum antibiotic concentration Bacteria mathematical model |
| Zdroj: | Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 1989, 33 (4), pp.535-40 |
| ISSN: | 0066-4804 1098-6596 |
| Popis: | International audience; The minimum antibiotic concentrations for selecting an R plasmid in vivo were determined in germfree mice colonized by two isogenic strains of Escherichia coli, one of which carried an R plasmid. Seventy groups of three gnotobiotic mice were given low doses of ampicillin, colistin, flumequin, gentamicin, tetracycline, or streptomycin via drinking water for 2 weeks. The equilibrium between susceptible and resistant populations of bacteria was monitored daily in feces and compared with that of control mice given pure water. This model yielded reproducible data, and dose and response were strongly correlated. The minimum selecting doses ranged from 0.9 to 12.8 micrograms/ml of water, depending on the antibiotic and the R plasmid. The use of mathematical models and complementary in vitro experiments accounted for the effect of the low antibiotic levels. |
| Databáze: | OpenAIRE |
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