Activating effect of adenosine on rat erythrocyte glycolysis
| Autor: | P.G. Blancas-Torres, Roger Gutierrez-Juarez, Vicente Madrid-Marina, E. Pi~Na, H. Martinez-Valdez, M. Castrejon-Sosa |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Erythrocytes Phosphofructokinase-1 Biology Biochemistry Enzyme activator Adenine nucleotide Internal medicine Fructosediphosphates medicine Animals Glycolysis Lactic Acid Phosphofructokinase 1 Rats Inbred Strains Rats Enzyme Activation Kinetics Red blood cell Endocrinology medicine.anatomical_structure Lactates Nucleoside medicine.drug Phosphofructokinase |
| Zdroj: | International Journal of Biochemistry. 24:433-436 |
| ISSN: | 0020-711X |
| DOI: | 10.1016/0020-711x(92)90036-z |
| Popis: | 1. Adenosine increases the adenine nucleotide pool in rat erythrocytes. Hence, we tested the effect of the nucleoside on the glycolytic pathway in red blood cells. 2. A 2.5-fold increase in the level of fructose-1,6-bisphosphate and a 34% augmentation in lactate pool were observed in rat erythrocytes, 30 min after adenosine treatment. 3. Under conditions preventing adenosine metabolism, 1 microM nucleoside addition to isolated erythrocytes induced an 89% increase in lactate production and an increase in glucose consumption. 4. Activation of red cell phosphofructokinase (PFK) is produced by addition of microM concentrations of adenosine. Our data suggest a role for adenosine in the glycolysis flux regulation through PFK activation. |
| Databáze: | OpenAIRE |
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