Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and 5-(hydroxymethyl) uracil in Smokers
| Autor: | Faranak Firoozi, Jean Hee, Alain Favier, Jean Cadet, Michelle Tripier, Véronique Ducros, Sandrine Pourcelot, Henri Faure |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Free Radicals Stereochemistry Urinary system Biochemistry Pentoxyl Excretion Nicotine chemistry.chemical_compound Internal medicine medicine Humans Deoxyguanosine Hydroxymethyl Creatinine Smoking 8-Hydroxy-2'-deoxyguanosine Uracil General Medicine Middle Aged Endocrinology chemistry 8-Hydroxy-2'-Deoxyguanosine Case-Control Studies Oxidation-Reduction DNA Damage medicine.drug |
| Zdroj: | Free Radical Research. 30:173-180 |
| ISSN: | 1029-2470 1071-5762 |
| DOI: | 10.1080/10715769900300191 |
| Popis: | Cigarette smoke is known to generate free radicals by various mechanisms. In this study involving 30 non-smokers and 30 smokers, we show that urinary excretion of 5-(hydroxymethyl) uracil (HMUra) was not different in the two groups (6.54+/-2.07 vs. 6.70+/-1.68 nmol/mmol creatinine). In contrast, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) excretion increased by 16% (1.16+/-0.35 vs. 1.35+/-0.50 nmol/mmol creatinine, p = 0.039). Results concerning 8-oxo-dGuo are in agreement with those of previous studies. We observed significant multiple correlations between HMUra and creatinine (r(p) = 0.44), BMI (r(p) = -0.27) and nicotine derivatives (r(p) = 0.26). Multiple correlation analysis showed relations between 8-oxo-dGuo on the one hand, and: creatinine (r(p) = 0.36), nicotine derivatives (r(p) = 0.29), BMI (r(p) = -0.24) on the other. |
| Databáze: | OpenAIRE |
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