Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
| Autor: | Orlando Ghirardi, Roberto Cozzolino, Alessandro Giuliani, Donatella Guaraldi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Aging Fischer 344 media_common.quotation_subject Longevity Zoology Biology Biochemistry Article Rats Sprague-Dawley Toxicology Life Expectancy Endocrinology Species Specificity Genetics Animals Molecular Biology Survival analysis media_common Principal Component Analysis Life span Strain (biology) Cell Biology Survival Analysis Rats Inbred F344 animal models Rats Sprague dawley Ageing Nonlinear Dynamics Regression Analysis phenotypic variability Gompertz' law Sprague-Dawley Gompertz–Makeham law of mortality life span |
| Zdroj: | Experimental Gerontology |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/0531-5565(95)00002-x |
| Popis: | The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fischer 344 rats showing a higher survival over the second year of life as well as a lower interindividual variability. A model-free approach based on principal component analysis allowed us to quantify these differences and to highlight some limitations of the classical Gompertzian approach. |
| Databáze: | OpenAIRE |
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