A new norcembranoid dimer from the red sea soft coral Sinularia gardineri
| Autor: | el Sayed Ka, Mark T. Hamann |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Cnidaria
Antifungal Agents Magnetic Resonance Spectroscopy Spectrophotometry Infrared Stereochemistry Dimer Alcyoniidae Pharmaceutical Science Antineoplastic Agents Sesquiterpene Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Lactones Mice Drug Discovery Candida albicans Tumor Cells Cultured Animals Humans Cytotoxicity Furans Pharmacology chemistry.chemical_classification biology Organic Chemistry biology.organism_classification Complementary and alternative medicine chemistry Cryptococcus neoformans Molecular Medicine Diterpene Drug Screening Assays Antitumor Coelenterata Lactone |
| Zdroj: | Journal of natural products. 59(7) |
| ISSN: | 0163-3864 |
| Popis: | A study of Sinularia gardineri (Pratt) (Alcyoniidae), collected in the Red Sea, revealed a new heptacyclic norcembranoid dimer singardin (1). The structure of singardin was deduced by spectroscopic analysis. A known sesquiterpene, guaianediol (2), and the known cembranolides (1R,5S,8R,10S,11R)-11-hydroxy-1-isoprenyl-8-methyl-3,6-dioxo -5,8-epoxycyclotetradec-12-ene 10,12-carbolactone (5-epi-sinuleptolide) and sinuleptolide were also isolated. Compounds 1 and 2 show cytotoxicity to murine leukemia (P-388), human lung carcinoma (A-549), human colon carcinoma (HT-29), and human melanoma cells (MEL-28). |
| Databáze: | OpenAIRE |
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