Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Autor: Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J.M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou
Přispěvatelé: Zhou, Yifan [0000-0002-3538-621X], Rogers, Stephanie N [0000-0002-4563-1899], Gu, Muxin [0000-0003-4376-795X], Fabre, Margarete A [0000-0001-7794-610X], Quiros, Pedro M [0000-0002-7793-6291], Shin, Tae-Hoon [0000-0002-9619-8554], Preller, Jacobus [0000-0001-5706-816X], Cobat, Aurélie [0000-0001-7209-6257], Rieux-Laucat, Frederic [0000-0001-7858-7866], Gaudinski, Martin R [0000-0002-3743-5281], Biondi, Andrea [0000-0002-6757-6173], Bonfanti, Paolo [0000-0001-7289-8823], Imberti, Luisa [0000-0002-2075-8391], Dobbs, Kerry [0000-0002-3432-3137], Notarangelo, Luigi D [0000-0002-8335-0262], Openshaw, Peter JM [0000-0002-7220-2555], Semple, Malcolm G [0000-0001-9700-0418], Mallat, Ziad [0000-0003-0443-7878], Baillie, Kenneth [0000-0001-5258-793X], Dunbar, Cynthia E [0000-0002-7645-838X], Vassiliou, George S [0000-0003-4337-8022], Apollo - University of Cambridge Repository, Zhou, Y, Shalhoub, R, Rogers, S, Yu, S, Gu, M, Fabre, M, Quiros, P, Diangson, A, Deng, W, Anand, S, Lu, W, Cullen, M, Godfrey, A, Preller, J, Hadjadj, J, Jouanguy, E, Cobat, A, Abel, L, Rieux-Laucat, F, Terrier, B, Fischer, A, Novik, L, Gordon, I, Strom, L, Gaudinski, M, Lisco, A, Sereti, I, Gniadek, T, Biondi, A, Bonfanti, P, Imberti, L, Zhang, Y, Dalgard, C, Dobbs, K, Su, H, Notarangelo, L, Wu, C, Openshaw, P, Semple, M, Mallat, Z, Baillie, K, Dunbar, C, Vassiliou, G
Rok vydání: 2022
Předmět:
Zdroj: Zhou, Y, Shalhoub, R N, Rogers, S N, Yu, S, Gu, M, Fabre, M A, Quiros, P M, Diangson, A, Deng, W, Anand, S, Lu, W, Cullen, M, Godfrey, A L, Preller, J, Hadjadj, J, Jouanguy, E, Cobat, A, Abel, L, Rieux-Laucat, F, Terrier, B, Fischer, A, Novik, L, Gordon, I J, Strom, L, Gaudinski, M, Lisco, A, Sereti, I, Gniadek, T J, Biondi, A, Bonfanti, P, Imberti, L, Zhang, Y, Dalgard, C L, Dobbs, K, Su, H C, Notarangelo, L D, Wu, C O, Openshaw, P J M, Semple, M G, Mallat, Z, Baillie, K, Dunbar, C E & Vassiliou, G S 2022, ' Clonal Hematopoiesis Is Not Significantly Associated with Covid-19 Disease Severity ', Blood, vol. 140, no. 14, pp. 1650-1655 . https://doi.org/10.1182/blood.2022015721
DOI: 10.1182/blood.2022015721
Popis: Clonal hematopoiesis (CH) describes the disproportionate expansion of a hematopoietic stemcell (HSC) and its progeny, in association with leukemia-associated somatic mutations, mostcommonly affecting the genes for epigenetic regulators DNMT3A, TET2 and ASXL1.The prevalence and size of such clones rise with age, in association with changes in the driver gene landscape.10 CH is associated with an increased risk of hematologic malignancies, but also of cardiovascular disease (CVD), independently of other known CVD risk factors.11,12 The basis forthis increased CVD risk has been linked to hyperinflammatory positive feedback loops driven by increased cytokine release from clonal myeloid cells, particularly interleukin IL-6 and IL-1β.
Databáze: OpenAIRE
Externí odkaz: