DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis
| Autor: | Qian Ys, Ji Rb, Hu Ar, Hu Yr |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Risk medicine.medical_specialty China Carcinoma Hepatocellular DNA Repair Genotype Subgroup analysis Bioinformatics Polymorphism Single Nucleotide Chinese hamster XRCC3 Asian People Internal medicine Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease Codon Molecular Biology Alleles Genetic Association Studies biology Liver Neoplasms Case-control study General Medicine Odds ratio biology.organism_classification medicine.disease DNA-Binding Proteins Amino Acid Substitution Meta-analysis Hepatocellular carcinoma Case-Control Studies Publication Bias |
| Zdroj: | Genetics and molecular research : GMR. 14(4) |
| ISSN: | 1676-5680 |
| Popis: | Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese population. Published literature from PubMed and China National Knowledge Infrastructure databases was retrieved, and a total of 5 case-control studies consisting of 2967 patients and 3874 controls were included in this meta-analysis, which revealed a significant association between the XRCC3 T241M polymorphism and HCC risk (TT vs MM: OR = 6.54, 95%CI = 2.14-19.99; TT vs MT: OR = 4.72, 95%CI = 2.26-9.86; dominant model: OR = 0.38, 95%CI = 0.26-0.57; recessive model: OR = 1.27, 95%CI = 0.99-1.62). In a subgroup analysis by sample size (number of subjects > 1000), similar results were obtained. Thus, XRCC3 T241M polymorphism may constitute a risk factor for HCC in the Chinese population. |
| Databáze: | OpenAIRE |
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