Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice
| Autor: | Shogo Yanai, Hiroshi Kitagawa, Yoshiaki Tabuchi, Toshifumi Yokoyama, Youhei Mantani, Naoki Yoneda, Tetsushi Hirano, Tadashi Takada, Anzu Yamamoto, Nobuhiko Hoshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Insecticides 040301 veterinary sciences dinotefuran Substantia nigra Biology Hyperkinesis Toxicology Guanidines Dinotefuran Open field 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Mice Neonicotinoids Dopamine Internal medicine neurobehavioral effect medicine Animals Sexual Maturation General Veterinary Tyrosine hydroxylase Dopaminergic Neurons Dopaminergic neonicotinoid 04 agricultural and veterinary sciences Note Nitro Compounds hyperactivity 030104 developmental biology Endocrinology Monoamine neurotransmitter chemistry dopamine Acetylcholine medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 0916-7250 |
| Popis: | Although neonicotinoid pesticides are expected to have harmful influence on mammals, there is little animal experimental data to support the effect and mechanisms. Since acetylcholine causes the release of dopamine, neonicotinoids may confer a risk of developmental disorders via a disturbance in the monoamine systems. Male mice were peripubertally administered dinotefuran (DIN) referring to no observed effect level (NOEL) and performed behavioral and immunohistological analyses. In an open field test, the total locomotor activity was increased in a dose-dependent manner. The immunoreactivity of tyrosine hydroxylase in the substantia nigra was increased in DIN-exposed mice. These results suggest that exposure to DIN in peripubertal male mice causes hyperactivity and a disturbance of dopaminergic signaling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|