Forced but not free-choice nicotine during lactation alters maternal behavior and noradrenergic system of pups: Impact on social behavior of adolescent isolated male rats
| Autor: | Marco Famele, Tiziana Pascucci, Emilia Romano, Rosanna Mancinelli, Doriana Chirico, Walter Adriani, Rosa Draisci |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Nicotine Weaning Choice Behavior 03 medical and health sciences 0302 clinical medicine Neurochemical Pregnancy Lactation Internal medicine medicine Animals Social isolation Maternal Behavior Behavior Animal General Neuroscience breast feeding tobacco smoking neurodevelopmental sequelae prefrontal cortex affiliative behavior juvenile rat medicine.disease Social relation Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Animals Newborn Social Isolation Maternal Exposure Prenatal Exposure Delayed Effects Female medicine.symptom Psychology Breast feeding 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience. 361 |
| ISSN: | 1873-7544 |
| Popis: | Adverse effects of nicotine during pregnancy have been greatly studied, while nowadays few works are focused on consequences of maternal tobacco smoking after birth. The present study investigated the behavioral and early neurochemical effects of nicotine treatment during first weeks of post-natal life in rats. We used "free choice" treatment (H2O+NIC dams could drink from two bottles, containing 10mg/L nicotine hydrogen tartrate salt, or water) versus "forced choice" (NIC+NIC mothers could drink from two bottles both containing nicotine hydrogen tartrate salt, range from 0.75mg/L to 4.09mg/L). We found that only "forced nicotine" had impact on maternal behavior, causing increased high-quality maternal care. This immediately impacted on neuro-chemical development, affecting NE levels (only males) in pup's striatum and prefrontal cortex (pFC) at PND 12. After weaning, animals were reared in normal conditions (two brother rats) or in Social Isolation. After two weeks, they were tested with Social Interaction Test (isolated rats met non-isolated opponents, siblings vs. non-siblings). As expected, isolated rats displayed an aggressive form of soliciting behavior: when facing an isolated unknown partner, the non-isolated rat tried to escape. Interestingly, if their dams were exposed to forced nicotine, both rats sooner behaved very affiliative (possibly empathic) between non-sibling partners. As expected, being exposed to post-natal nicotine could alter neuro-chemical development, but with important interactions between both maternal care and adolescent social behavior. |
| Databáze: | OpenAIRE |
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