Characterization of liposomal vesicles encapsulating rhodanese for cyanide antagonism

Autor:	Mária Szilasi, Imre Klebovich, Ilona Petrikovics, Pál Gróf, J. Childress, Gary A. Rockwood, Lívia Budai, Steven I. Baskin, Marianna Budai
Rok vydání:	2009
Předmět:	Liposome Cyanides Osmotic concentration Thiocyanate Viscosity Cyanide Vesicle Pharmaceutical Science Sulfurtransferase General Medicine Rhodanese Thiosulfate Sulfurtransferase chemistry.chemical_compound chemistry Biochemistry In vivo Liposomes
Zdroj:	Drug Delivery. 16:312-319
ISSN:	1521-0464 1071-7544
Popis:	The major mechanism of removing cyanide from the body is its enzymatic conversion by a sulfurtransferase, e.g. rhodanese, to the less toxic thiocyanate in the presence of a sulfur donor. Earlier results demonstrated that externally administered encapsulated rhodanese significantly enhances the in vivo efficacy of the given sulfur donor. Present studies are focused on liposomal carrier systems encapsulating rhodanese. Physicochemical properties, e.g. membrane rigidity, size distribution, surface potential, osmolarity, and viscosity, were determined for various liposomal lipid compositions and hydrating buffers to establish in vitro stability and in vivo fate. Lipid composition was also optimized to achieve maximum encapsulation efficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b32d77e27f036a3d611b58d8f6a7ce https://doi.org/10.1080/10717540903003711 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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