Two susceptibility loci identified for prostate cancer aggressiveness

Autor: Berndt, Si, Wang, Z, Yeager, M, Alavanja, Mc, Albanes, D, Amundadottir, L, Andriole, G, Beane Freeman, L, Campa, D, Cancel-Tassin, G, Canzian, F, Cornu, Jn, Cussenot, O, Diver, Wr, Gapstur, Sm, Grönberg, H, Haiman, Ca, Henderson, B, Hutchinson, A, Hunter, Dj, Key, Tj, Kolb, S, Koutros, S, Kraft, P, Le Marchand, L, Lindström, S, Machiela, Mj, Ostrander, Ea, Riboli, E, Schumacher, F, Siddiq, A, Stanford, Jl, Stevens, Vl, Travis, Rc, Tsilidis, Kk, Virtamo, J, Weinstein, S, Wilkund, F, Xu, J, Lilly Zheng, S, Yu, K, Wheeler, W, Zhang, H, African, Ancestry Prostate Cancer GWAS Consortium, Sampson, J, Black, A, Jacobs, K, Hoover, Rn, Tucker, M, Chanock, Sj. Ingles SA, Kittles, Ra, Strom, Ss, Rybicki, Ba, Nemesure, B, Isaacs, Wb, Zheng, W, Pettaway, Ca, Yeboah, Ed, Tettey, Y, Biritwum, Rb, Adjei, Aa, Tay, E, Truelove, A, Niwa, S, Chokkalingam, Ap, John, Em, Murphy, Ab, Signorello, Lb, Carpten, J, Leske, Mc, Wu, Sy, Hennis, Aj, Neslund-Dudas, C, Hsing, Aw, Chu, L, Goodman, Pj, Klein, Ea, Witte, Js, Casey, G, Kaggwa, S, Cook, Mb, Stram, Do, Blot, Wj.
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Oncology
Male
Aging
GLEASON SCORE
LINKAGE SCAN
General Physics and Astronomy
Genome-wide association study
Disease
Bioinformatics
Prostate cancer
SEQUENCE VARIANTS
Medicine
2.1 Biological and endogenous factors
GTPASE-ACTIVATING PROTEIN
Aetiology
POPULATION
Cancer
RISK
education.field_of_study
African Ancestry Prostate Cancer GWAS Consortium
Multidisciplinary
Prostate Cancer
3. Good health
Multidisciplinary Sciences
Science & Technology - Other Topics
Urologic Diseases
medicine.medical_specialty
Population
Article
General Biochemistry
Genetics and Molecular Biology
GENOME-WIDE ASSOCIATION
BASE-LINE CHARACTERISTICS
COHORT
METAANALYSIS
Internal medicine
Genetics
SNP
Humans
Neoplasm Invasiveness
Genetic Predisposition to Disease
education
Pathological
Science & Technology
business.industry
Vascular disease
Prevention
Human Genome
Case-control study
Prostatic Neoplasms
General Chemistry
medicine.disease
Genetic Loci
Case-Control Studies
Neoplasm Grading
business
Zdroj: Nature communications, vol 6, iss 1
Nature communications
Popis: Most men diagnosed with prostate cancer will experience indolent disease; hence, discovering genetic variants that distinguish aggressive from nonaggressive prostate cancer is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study of 12,518 prostate cancer cases, we identify two loci associated with Gleason score, a pathological measure of disease aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49 × 10(-9)) and rs78943174 at 3q26.31 (NAALADL2, P=4.18 × 10(-8)). In a stratified case-control analysis, the SNP at 5q14.3 appears specific for aggressive prostate cancer (P=8.85 × 10(-5)) with no association for nonaggressive prostate cancer compared with controls (P=0.57). The proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation.
Databáze: OpenAIRE
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