Sex differences in long-term outcomes after traumatic injury: A mediation analysis
| Autor: | George Kasotakis, Christina Weed, Karen J. Brasel, Mohamad El Moheb, Adil H. Haider, George C. Velmahos, Ali Salim, Deepika Nehra, Juan P. Herrera-Escobar, Haytham M.A. Kaafarani, Molly P. Jarman, Anju Ranjit |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty business.industry Female sex General Medicine Middle Aged Trauma outcomes Posttraumatic stress Traumatic injury Sex Factors Risk Factors Internal medicine Extremity injury Female patient Outcome Assessment Health Care medicine Long term outcomes Humans Wounds and Injuries Surgery Functional status Female Prospective Studies business Aged |
| Zdroj: | American journal of surgery. 222(4) |
| ISSN: | 1879-1883 |
| Popis: | Background We sought to examine the association and potential mediators between sex and long-term trauma outcomes. Methods Moderately-to-severely injured patients admitted to 3 level-1 trauma centers were contacted between 6 and 12-months post-injury to assess for functional limitations, use of pain medications, and posttraumatic stress disorder (PTSD). Multivariable adjusted regression analyses were used to compare long-term outcomes by sex. Potential mediators of the relationship between sex and outcomes was explored using mediation analysis. Results 2607 patients were followed, of which 45% were female. Compared to male, female patients were more likely to have functional limitations (OR: 1.45; 95% CI: 1.31–1.60), take pain medications (OR: 1.17; 95% CI: 1.02–1.38), and screen positive for PTSD (OR: 1.60; 95% CI: 1.46–1.76) post-injury. Age, extremity injury, previous psychiatric illness, and pre-injury unemployment, partially mediated the effect of female sex on long-term outcomes. Conclusions There are significant sex differences in long-term trauma outcomes, which are partially driven by patient and injury-related factors. |
| Databáze: | OpenAIRE |
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