Quantitative analysis of interferon α/β receptor mRNA in the liver of patients with chronic hepatitis C: Correlation with serum hepatitis C virus-RNA levels and response to treatment with interferon
| Autor: | Kazumi Yamasaki, Osami Inoue, Hiroshi Yatsuhashi, Michiaki Koga, Michitami Yano, P. Maria, D. Carmen, Tomoyuki Aritomi |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Hepatitis C virus Gene Expression Alpha interferon medicine.disease_cause Polymerase Chain Reaction Virus Interferon Internal medicine medicine Humans RNA Messenger Receptor Interferon alfa Aged Receptors Interferon Messenger RNA Hepatology Sequence Analysis RNA business.industry Gastroenterology Interferon-alpha RNA Alanine Transaminase Middle Aged Hepatitis C Endocrinology Liver Chronic Disease Immunology RNA Viral Female business medicine.drug |
| Zdroj: | Journal of Gastroenterology and Hepatology. 12:460-467 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1111/j.1440-1746.1997.tb00467.x |
| Popis: | We analysed the expression of interferon (IFN) alpha/beta receptor mRNA in the liver of patients with chronic hepatitis C and examined the relationship between the expression of this receptor gene and the level of hepatitis C virus (HCV)-RNA as well as the response to 16 weeks of 6 x 10(6) units IFN. The mean level of IFN alpha/beta receptor mRNA in patients with chronic HCV infection (expressed as delta cycle; 10.8 +/- 1.9 (mean +/- SD); n = 39) was significantly higher than that of control subjects (9.4 +/- 0.5; n = 6; P0.01). There was a significant negative correlation between the level of IFN alpha/beta receptor mRNA and serum HCV-RNA in 39 patients with chronic hepatitis C (R = -0.546; P0.01). The mean level of IFN alpha/beta receptor mRNA in six patients who showed a complete response to IFN therapy (12.3 +/- 1.6) was higher than that of 15 patients who failed to respond to therapy (10.1 +/- 1.5; P0.01). Our results are consistent with the suggestion that the anti-viral activity of IFN depends on the level of the IFN alpha/beta receptor on hepatocytes in patients with chronic hepatitis C. |
| Databáze: | OpenAIRE |
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