Synthesis of Bis (2,2,6,6-tetramethyl-4-piperidinyl) Maleate
| Autor: | Shengli Zhai, Fu An Wang, Jiqin Zhu, Lei Wang, Jianchi Song |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Pharmaceutical Science
Infrared spectroscopy 6-tetramethyl-4-piperidinyl) maleate Article Analytical Chemistry Catalysis Reaction rate molecular synthesis lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Organic chemistry Physical and Theoretical Chemistry Hindered amine light stabilizers Chemistry Bis (2 2 6 6-tetramethyl-4-piperidinyl) maleate Organic Chemistry Dimethyl maleate Nuclear magnetic resonance spectroscopy Chemistry (miscellaneous) Bis (2 Yield (chemistry) 2 6 Molecular Medicine Selectivity Nuclear chemistry |
| Zdroj: | Molecules, Vol 6, Iss 6, Pp 528-532 (2001) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules; Volume 6; Issue 6; Pages: 528-532 |
| ISSN: | 1420-3049 |
| Popis: | Bis (2,2,6,6-tetramethyl-4-piperidinyl) maleate is a key intermediate for the synthesis of new types of hindered amine light stabilizers (HALS), so new synthetic routes to this compound are desirable. Through an orthogonal design and follow-up single factor experiments optimal reaction conditions were determined for synthesizing bis (2,2,6,6-tetramethyl-4-piperidiny) maleate using dimethyl maleate, 2,2,6,6-tetramethyl-4-piperidinol and zeolite supported tetraisopropyl titanate as catalyst. Under the selected conditions, the reaction rate and the yield are high, the selectivity is good, the catalyst can be recycled, and there are fewer wastes. The product was characterized and quantitatively analyzed by elemental analysis, mass spectrometry, infrared spectroscopy, nuclear magnetic resonance spectroscopy and ion suppression chromatography. |
| Databáze: | OpenAIRE |
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