Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content
| Autor: | R. N. Lonsdale, Dd D. Giri, J. C. E. Underwood, N. Rooney |
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| Rok vydání: | 1987 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Lymphokine-activated killer cell Stromal cell Cluster of differentiation medicine.drug_class Breast Neoplasms Biology Adenocarcinoma medicine.disease Monoclonal antibody Natural killer T cell Killer Cells Natural Leukocyte Count Immunophenotyping Oncology Receptors Estrogen medicine Humans Female Lymphocytes Receptor Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the infiltrating lymphoid cells and related this to the tumour ER content. There is a significant inverse correlation between the presence of Leu7-positive cells, which includes a subpopulation of natural killer (NK) cells, and tumour ER content; this is possibly superimposed on the dilutional effect of macrophages and other infiltrating cells. Images Figure 1 |
| Databáze: | OpenAIRE |
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