Effect of combined periodontal-orthodontic treatment on NOD-like receptor protein 3 and high mobility group box-1 expressions in patients with periodontitis and its clinical significance
Autor: | Zicheng Wei, Chen Zhou, Zhanai Shi, Lihua Yu |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male combined periodontal-orthodontic treatment medicine.medical_specialty Observational Study Orthodontics chemical and pharmacologic phenomena HMGB1 Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine NLR Family Pyrin Domain-Containing 3 Protein medicine Humans Clinical significance 030212 general & internal medicine HMGB1 Protein periodontitis high-mobility group box-1 Periodontitis integumentary system biology business.industry Case-control study NOD-like receptor Gingival Crevicular Fluid General Medicine Periodontology Middle Aged medicine.disease Combined Modality Therapy Chronic periodontitis Treatment Outcome High-mobility group Case-Control Studies 030220 oncology & carcinogenesis Chronic Disease Chronic Periodontitis NOD-like receptor protein 3 biology.protein Periodontics Female business Research Article |
Zdroj: | Medicine |
ISSN: | 1536-5964 0025-7974 |
DOI: | 10.1097/md.0000000000017724 |
Popis: | To investigate the effect of combined periodontal-orthodontic treatment on the gingival crevicular fluid (GCF) levels of high mobility group box-1 (HMGB1) and NOD-like receptor protein 3 (NLRP3) in chronic periodontitis. A total of 60 patients with periodontitis who received combined periodontal-orthodontic treatment and 32 healthy individuals as normal controls were recruited in this study. Periodontal parameters were recorded. Enzyme-linked immunosorbent assay (ELISA) was used to examine GCF levels of HMGB1 and NLRP3. The periodontal parameters and GCF levels of HMGB1 and NLRP3 in periodontitis patients were significantly higher before treatment, and observably decreased after 6 months of treatment as compared with the healthy group. However, significant positive correlations were observed between HMGB1, NLRP3, and periodontal parameters in chronic periodontitis patients. Patients with chronic periodontitis showed higher levels of HMGB1 and NLRP3 in GCF. |
Databáze: | OpenAIRE |
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