Effect of combined periodontal-orthodontic treatment on NOD-like receptor protein 3 and high mobility group box-1 expressions in patients with periodontitis and its clinical significance

Autor: Zicheng Wei, Chen Zhou, Zhanai Shi, Lihua Yu
Rok vydání: 2019
Předmět:
Adult
Male
combined periodontal-orthodontic treatment
medicine.medical_specialty
Observational Study
Orthodontics
chemical and pharmacologic phenomena
HMGB1
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
NLR Family
Pyrin Domain-Containing 3 Protein

medicine
Humans
Clinical significance
030212 general & internal medicine
HMGB1 Protein
periodontitis
high-mobility group box-1
Periodontitis
integumentary system
biology
business.industry
Case-control study
NOD-like receptor
Gingival Crevicular Fluid
General Medicine
Periodontology
Middle Aged
medicine.disease
Combined Modality Therapy
Chronic periodontitis
Treatment Outcome
High-mobility group
Case-Control Studies
030220 oncology & carcinogenesis
Chronic Disease
Chronic Periodontitis
NOD-like receptor protein 3
biology.protein
Periodontics
Female
business
Research Article
Zdroj: Medicine
ISSN: 1536-5964
0025-7974
DOI: 10.1097/md.0000000000017724
Popis: To investigate the effect of combined periodontal-orthodontic treatment on the gingival crevicular fluid (GCF) levels of high mobility group box-1 (HMGB1) and NOD-like receptor protein 3 (NLRP3) in chronic periodontitis. A total of 60 patients with periodontitis who received combined periodontal-orthodontic treatment and 32 healthy individuals as normal controls were recruited in this study. Periodontal parameters were recorded. Enzyme-linked immunosorbent assay (ELISA) was used to examine GCF levels of HMGB1 and NLRP3. The periodontal parameters and GCF levels of HMGB1 and NLRP3 in periodontitis patients were significantly higher before treatment, and observably decreased after 6 months of treatment as compared with the healthy group. However, significant positive correlations were observed between HMGB1, NLRP3, and periodontal parameters in chronic periodontitis patients. Patients with chronic periodontitis showed higher levels of HMGB1 and NLRP3 in GCF.
Databáze: OpenAIRE