Possible association of ?-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia
| Autor: | Tatsuyo Suzuki, Toshiya Inada, Tsuyoshi Kitajima, Mitsuhiko Yamada, Yoshimoto Sekine, Ichiro Sora, Hiroshi Ujike, Taro Kishi, Mutsuo Harano, Nakao Iwata, Masaomi Iyo, Yoko Kinoshita, Tokutaro Komiyama, Norio Ozaki, Masashi Ikeda, Yoshio Yamanouchi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Arrestins Amphetamine-Related Disorders Single-nucleotide polymorphism Pharmacology Polymorphism Single Nucleotide Linkage Disequilibrium Methamphetamine Behavioral Neuroscience chemistry.chemical_compound Internal medicine Genotype Genetics medicine Humans Allele GSK3B beta-Arrestins Genetic association Chi-Square Distribution Beta-Arrestins Meth Middle Aged medicine.disease beta-Arrestin 2 Endocrinology Neurology chemistry Schizophrenia Case-Control Studies Female Psychology |
| Zdroj: | Genes, Brain and Behavior. 6:107-112 |
| ISSN: | 1601-183X 1601-1848 |
| Popis: | Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder. One important molecule related to this cascade is beta-arrestin 2 (ARRB2). We therefore conducted a genetic case-control association analysis of the gene for ARRB2 with schizophrenia and METH use disorder in a Japanese population (547 people with schizophrenia, 177 with METH use disorder and 546 controls). A possible association of 'tag single nucleotide polymorphisms (SNPs)' was found in METH use disorder (rs1045280: P(genotype) = 0.0118, P(allele) = 0.00351; rs2036657: P(allele) = 0.0431; rs4790694: P(genotype) = 0.0167, P(allele) = 0.0202), but no association was found with schizophrenia. We also evaluated the gene-gene interactions among ARRB2, AKT1, and GSK3B, which we previously reported for each of these diseases. However, no interaction was seen in our samples. This is the first association analysis of ARRB2, and our results indicate that ARRB2 may play a role in the pathophysiology of METH use disorder. |
| Databáze: | OpenAIRE |
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