Characteristics of muscarinic cholinergic, gamma-aminobutyric acid(A) and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis
| Autor: | Kenshi Murase, Junzo Yamada, Tadao Serikawa, Tsutomu Kameyama, Toshitaka Nabeshima, Kumatoshi Ishihara, Shuji Takaori, Masashi Sasa, Hisamitsu Ujihara |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Phencyclidine Striatum Tonic Convulsion Tritium Rats Mutant Strains chemistry.chemical_compound Internal medicine Convulsion medicine Animals Receptor Epilepsy GABAA receptor Muscimol General Neuroscience Brain Receptors GABA-A Receptors Muscarinic Quinuclidinyl Benzilate Rats Receptors Neurotransmitter Endocrinology chemistry Organ Specificity Autoradiography Female Receptors Phencyclidine medicine.symptom medicine.drug |
| Zdroj: | Neuroscience letters. 131(1) |
| ISSN: | 0304-3940 |
| Popis: | Characteristics of muscarinic cholinergic (mACh), γ-aminobutyric acid A (GABA A ) and phencyclidine (PCP) receptors in the spontaneously epileptic rats (SER), which exhibit both absence-like seizures and tonic convulsion, were examined using in vitro quantitative autoradiography. Computer analysis using autoradiographic technique revealed that the amount of the specific binding of [ 3 H]quinuclidinyl benzilate (QNB) to mACh receptors in the striatum of SER was more than that of zitter rats, not exhibiting both seizures and convulsion. However, the specific bindings of [ 3 H]muscimol and [ 3 H]N-(2-thienyl)cyclohexyl)3,4-piperidine (TCP) to GABA A and PCP receptors, respectively, of SER were not different from those of zitter rats in various regions tested. These results suggest that hyperfunction of mACh receptors in the striatum is involved in the appearance of absence-like seizures and tonic convulsion of SER. |
| Databáze: | OpenAIRE |
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