Hypoglycemic and pancreatic protective effects of Portulaca oleracea extract in alloxan induced diabetic rats

Autor: Amina M. Tolba, Basma K. Ramadan, Mona F. Schaalan
Rok vydání: 2017
Předmět:
Blood Glucose
Male
0301 basic medicine
medicine.medical_treatment
law.invention
chemistry.chemical_compound
0302 clinical medicine
law
Alloxan
Insulin
biology
C-peptide
Diabetes
General Medicine
Liver
030220 oncology & carcinogenesis
Research Article
medicine.medical_specialty
Portulaca
Carbohydrate metabolism
Protective Agents
Diabetes Mellitus
Experimental

03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Animals
Humans
Hypoglycemic Agents
Rats
Wistar

Pancreas
Glycemic
Glycated Hemoglobin
IL-6
Interleukin-6
Plant Extracts
Tumor Necrosis Factor-alpha
business.industry
medicine.disease
biology.organism_classification
Rats
030104 developmental biology
Endocrinology
Complementary and alternative medicine
chemistry
TNF-α
Portulaca oleracea
B-cell mass
Phytotherapy
business
Zdroj: BMC Complementary and Alternative Medicine
ISSN: 1472-6882
DOI: 10.1186/s12906-016-1530-1
Popis: Background Diabetes is a major public health concern. In spite of continuous new drug development to treat diabetes, herbal remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Portulaca oleracea has been traditionally used to manage several diseases due to the anti-oxidant and anti-atherogenic effects it imparts. To better understand the mechanisms associated with potential protective effect of P. oleracea extract against diabetes, alloxan-induced diabetic rats were used in this study. Methods Forty Wistar rats (male, 7–8-wk-old, 140–160 g) were divided into four groups (n = 10/group): Group I (control), Group II (P. oleracea-treated; gavaged with P. oleracea extract daily [at 250 mg/kg] for 4 weeks), Group III (diabetic control; daily IP injection of alloxan [at 75 mg/kg] for 5 days) and Group IV (P. oleracea-pre-treated diabetic; gavaged with P. oleracea extract daily [at 250 mg/kg] for 4 weeks and then daily IP injection of alloxan [at 75 mg/kg] for 5 days). Body weight, food consumption, blood (serum) levels of glucose, C peptide, Hb A1C, insulin, tumor necrosis factor (TNF)-α and interleukin (IL)-6 were determined for all groups. Results The results indicated that while Hb A1C, serum levels of glucose, TNF-α and IL-6 were all significantly decreased in the P. oleracea-pre-treated diabetic rats, these hosts also had significant increases in C peptide and insulin compared to levels in the counterpart diabetic rats. These results were confirmed by the histopathological assessments which showed marked improvement of the destructive effect on pancreatic islet cells induced by alloxan. Conclusion P. oleracea extract is a general tissue protective and regeneartive agent, as evidenced by increasing β-cell mass and therefore improved the glucose metabolism. Thus, stimulation of Portulaca oleracea signaling in β- cells may be a novel therapeutic strategy for diabetes prevention.
Databáze: OpenAIRE