Hypoglycemic and pancreatic protective effects of Portulaca oleracea extract in alloxan induced diabetic rats
Autor: | Amina M. Tolba, Basma K. Ramadan, Mona F. Schaalan |
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Rok vydání: | 2017 |
Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_treatment law.invention chemistry.chemical_compound 0302 clinical medicine law Alloxan Insulin biology C-peptide Diabetes General Medicine Liver 030220 oncology & carcinogenesis Research Article medicine.medical_specialty Portulaca Carbohydrate metabolism Protective Agents Diabetes Mellitus Experimental 03 medical and health sciences Internal medicine Diabetes mellitus medicine Animals Humans Hypoglycemic Agents Rats Wistar Pancreas Glycemic Glycated Hemoglobin IL-6 Interleukin-6 Plant Extracts Tumor Necrosis Factor-alpha business.industry medicine.disease biology.organism_classification Rats 030104 developmental biology Endocrinology Complementary and alternative medicine chemistry TNF-α Portulaca oleracea B-cell mass Phytotherapy business |
Zdroj: | BMC Complementary and Alternative Medicine |
ISSN: | 1472-6882 |
DOI: | 10.1186/s12906-016-1530-1 |
Popis: | Background Diabetes is a major public health concern. In spite of continuous new drug development to treat diabetes, herbal remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Portulaca oleracea has been traditionally used to manage several diseases due to the anti-oxidant and anti-atherogenic effects it imparts. To better understand the mechanisms associated with potential protective effect of P. oleracea extract against diabetes, alloxan-induced diabetic rats were used in this study. Methods Forty Wistar rats (male, 7–8-wk-old, 140–160 g) were divided into four groups (n = 10/group): Group I (control), Group II (P. oleracea-treated; gavaged with P. oleracea extract daily [at 250 mg/kg] for 4 weeks), Group III (diabetic control; daily IP injection of alloxan [at 75 mg/kg] for 5 days) and Group IV (P. oleracea-pre-treated diabetic; gavaged with P. oleracea extract daily [at 250 mg/kg] for 4 weeks and then daily IP injection of alloxan [at 75 mg/kg] for 5 days). Body weight, food consumption, blood (serum) levels of glucose, C peptide, Hb A1C, insulin, tumor necrosis factor (TNF)-α and interleukin (IL)-6 were determined for all groups. Results The results indicated that while Hb A1C, serum levels of glucose, TNF-α and IL-6 were all significantly decreased in the P. oleracea-pre-treated diabetic rats, these hosts also had significant increases in C peptide and insulin compared to levels in the counterpart diabetic rats. These results were confirmed by the histopathological assessments which showed marked improvement of the destructive effect on pancreatic islet cells induced by alloxan. Conclusion P. oleracea extract is a general tissue protective and regeneartive agent, as evidenced by increasing β-cell mass and therefore improved the glucose metabolism. Thus, stimulation of Portulaca oleracea signaling in β- cells may be a novel therapeutic strategy for diabetes prevention. |
Databáze: | OpenAIRE |
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